Rivka (Rebecca) gives birth to Esav (Esau) and Ya'akov (Jacob). Esav sells the birthright to Ya'akov for a bowl of lentil soup. Yitzchak (Isaac) sojourns in Gerar with Avimelech (Avimelech), king of the Philistines. Esav marries two Hittite women bringing great pain to his parents (because they weren't of the fold).
Ya'akov impersonates Esav on the counsel of his mother in order to receive the blessing for the oldest son from his blind father, Yitzchak. Esav, angry because of his brother's deception which caused him to lose the firstborn blessings, plans to kill Ya'akov, so Ya'akov flees to his uncle Lavan (Laban) in Padan Aram -- on the advice of his parents. They also advise him to marry Lavan's daughter.
Esav understands that his Canaanite wives are displeasing to his parents, so he marries a third wife, Machlath, the daughter of Ishmael.